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T16079 |
Mirodenafil
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SK3530 |
PDE
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Mirodenafil is a PDE-5 inhibitor developed for the treatment of erectile dysfunction. |
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T9079 |
Apostatin-1
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Apt-1 |
Others
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Apostatin-1 (Apt-1) is a novel TRADD inhibitor. Apostatin-1 can bind to a pocket on the N-terminal TRAF2 binding domain of TRADD. |
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TQ0126 |
Mirodenafil dihydrochloride
|
SK-3530 dihydrochloride |
PDE
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Mirodenafil dihydrochloride is a PDE-5 inhibitor developed for the treatment of erectile dysfunction. |
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T12352L |
Oxidopamine hydrobromide
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6-Hydroxydopamine hydrobromide,6-OHDA hydrobromide |
Mitophagy
,
Dopamine Receptor
,
Autophagy
|
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Oxidopamine hydrobromide (6-OHDA hydrobromide) is a neurotransmitter dopamine antagonist. |
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T12352 |
Oxidopamine hydrochloride
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6-Hydroxydopamine hydrochloride,6-OHDA hydrochloride |
Mitophagy
,
Dopamine Receptor
,
Autophagy
|
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Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is an neurotransmitter dopamine antagonist. |
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T39195 |
YM-244769 dihydrochloride
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Calcium Channel
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YM-244769 dihydrochloride is an effective inhibitor of Na+/Ca2+ exchange 3 (NCX3) with an IC50 of 18 nM. YM-244769 dihydrochloride has efficient protective effects on neurons and kidneys. |
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T9888 |
YM-244769
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3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]- |
Calcium Channel
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YM-244769 (3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-) is an effective inhibitor of Na+/Ca2+ exchange 3 (NCX3) with an IC50 of 18 nM. YM-244769 has efficient protective effec... |
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T40063 |
CBR-470-1
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Nrf2
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CBR-470-1 is a potent inhibitor of glycolytic phosphoglycerate kinase 1 (PGK1) that activates NRF2 by increasing methylglyoxal levels. CBR-470-1 is a non-covalent Nrf2 activator with neuroprotective activity that protect... |
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T9169 |
MPP+ iodide
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Mitochondrial Metabolism
,
Autophagy
|
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MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) ex... |
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T35689 |
MTP 131 acetate
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Others
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MTP 131 is a mitochondria-targeted peptide antioxidant.1,2It localizes to the mitochondria and reducestert-butyl hydroperoxide-induced lipid peroxidation and apoptosis in SH-SY5Y cells when used at concentrations ranging... |
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T15412 |
GPP78
|
CAY10618 |
Autophagy
|
|
GPP78 is a potent inhibitor of Nampt (IC50: 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion). GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells (IC50: 3.8 nM by inducing autophagy). GPP78 has anti-... |
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T26821 |
BIPM
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|
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BIPM is a potent inhibitor of Rho-associated protein kinase 2 (ROCK2). Exposure of SH-SY5Y cells to BIPM led to significant changes in cell migration, actin stress fibers and neurite length. BIPM significantly inhibits p... |
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T60792 |
NMDA receptor antagonist-3
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|
|
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NMDA receptor antagonist-3 is a NMDA receptor antagonist with a significan recovery rate (40.0%, at 100 μM) and safe toxicological characteristics in SH-SY5Y and human adipose mesenchymal stem cells. |
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T26705 |
AZ-4217
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AZ4217,AZ 4217 |
|
|
AZ-4217 is a high potency BACE inhibitor. It displays acute central efficacy in different in vivo models and reduced amyloid deposition in Tg2576 mice. AZ-4217 has IC50 160 pM in human SH-SY5Y cells with an excellent in ... |
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T36427 |
PACAP (6-27) (human, chicken, mouse, ovine, porcine, rat) (trifluoroacetate salt)
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PACAP
|
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Pituitary adenylate cyclase-activating peptide (PACAP) (6-27) is a PACAP receptor antagonist with IC50 values of 1,500, 600, and 300 nM, respectively, for rat PAC1, rat VPAC1, and human VPAC2 recombinant receptors expres... |
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T71026 |
MC2050 HCl
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|
|
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MC2050 is a potent PARP-1 inhibitor. The IC50 for inhibition of PARP-1 activity is 119 nM, compared to 1.8 μM for PARP-2. MC2050 inhibits apoptosis and blocks poly ADP-ribosylation of histone H1 in hydrogen peroxide trea... |
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T63628 |
AChE-IN-19
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|
|
|
AChE-IN-19 is a potent inhibitor of AChE (IC50: 0.56 μM) and also exhibits inhibition of Aβ aggregation. aChE-IN-19 exhibits neuroprotective effects and is virtually non-toxic to SH-SY5Y cells. aChE-IN-19 can be used to ... |
|
T60748 |
ZDWX-25
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|
|
|
ZDWX-25 is a highly potent dual inhibitor of GSK-3β and DYRK1A that possesses significant cytotoxic activities towards SH-SY5Y and HL-7702 cells. ZDWX-25 can be used for Alzheimer's disease research with an IC 50 value o... |
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T28160 |
Nerispirdine HCl
|
HP-184,HP 184,Nerispirdine hydrochloride,HP184 |
|
|
Nerispirdine is a acetylcholine release enhancer, sodium channel blocker and K(V) 2.1 channel blocker. Nerispirdine inhibits voltage-dependent Na(+) channel currents recorded from human SH-SY5Y cells with an IC(50) of 11... |
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T60528 |
PDPOB
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|
|
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PDPOB is a phenyl carboxylic acid derivative with the potential to be used in the study of cerebral ischemia. PDPOB is shown to be protective against OGD/R-evoked multi-aspect neuronal deterioration in SH-SY5Y cells, as ... |
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T37578 |
GPP 78 hydrochloride
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|
|
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GPP 78 hydrochloride is a potent inhibitor of nicotinamide phosphoribosyltransferase (Nampt) with an IC50 of 3 nM for NAD depletion. GPP 78 hydrochloride is toxic to neuroblastoma cells SH-SY5Y via induction of autophagy... |
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T80516 |
Human GALP (3-32)
|
Galanin-like peptide (3-32) |
Neuropeptide Y Receptor
|
|
Human GALP (3-32) (Galanin-like peptide (3-32)) serves as a high-affinity agonist for galanin receptors GalR1 (IC50 = 33 nM) and GalR2 (IC50 = 15 nM), as evidenced by competitive binding studies. It demonstrates signific... |
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T63873 |
Anti-Aβ agent 1A
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|
|
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Anti-Aβ agent 1A is a potent anti-amyloid-β agent. Anti-Aβ agent 1A significantly inhibits LPS-induced IL-1β, IL-6 and TNF-α levels and reduces H2O2-induced apoptosis in SH-SY5Y cells using the mitochondrial pathway, exh... |
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T73658 |
Orexin A (human, rat, mouse) (acetate)
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|
|
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Orexin A (Hypocretin-1) (human, rat, mouse) acetate, a hypothalamic neuropeptide with analgesic abilities that penetrates the blood-brain barrier, acts as an OX1R agonist. It promotes the expression of BDNF and TH protei... |
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T68547 |
SNJ-1945
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|
|
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SNJ-1945 is a calpain inhibitor with more favorable retinal penetration, high oral bioavailability, and long half-life. SNJ1945 rescued defective function in lissencephaly. SNJ-1945 protects SH-SY5Y cells against MPP(+) ... |
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T81867 |
MAO-B-IN-26
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|
Autophagy
|
|
MAO-B-IN-26 (Compound IC9) serves as both a MAO-B and acetylcholinesterase inhibitor. It safeguards SH?SY5Y cells from Aβ-induced toxicity, including morphological alterations, reactive oxygen species (ROS) production, a... |
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T35745 |
Marcfortine A
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|
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Marcfortine A is an indole alkaloid originally isolated from P. roqueforti. It has nematocidal activity against the parasitic nematode H. contortus (LD99 = 0.06 μg/ml) and inhibits motility of adult worms (EC50 = 2 μM).,... |
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T83875 |
HUP-55
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|
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HUP-55 is a prolyl endopeptidase inhibitor with an IC50 of 5 nM, shown to mitigate α-synuclein dimerization in Neuro2a cells, stimulate autophagy in HEK293 cells, and lower hydrogen peroxide-evoked reactive oxygen specie... |
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T35811 |
CAY10410
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|
|
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CAY10410 is an analog of prostaglandin D2/prostaglandin J2 (PGD2/PGJ2) with structural modifications intended to give it PPARγ ligand activity and resistance to metabolism. 15-deoxy-δ12,14-PGJ2 has been shown to be a pot... |
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T36554 |
TMB 8 (hydrochloride)
|
|
|
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TMB 8 is a non-competitive antagonist of nicotinic acetylcholine receptors (nAChRs) with IC50 values of 390 and 350 nM, respectively, for human muscle-type and α3β4 subunit-containing ganglionic nAChRs expressed in TE671... |
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T37114 |
SB 242084 dihydrochloride
|
|
|
|
SB 242084 hydrochloride is a 5-HT2C receptor antagonist(pKi=9.0) that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively.IC50 value: 9.0(pKi) [1]Target: 5-HT2C antagonistin vitro: SB 242... |
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T37202 |
CC4
|
CC4 |
|
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High affinity and subtype selective α6β2 and α4β2 partial agonist (Ki values are 12 and 26nM for rat α6β2 and α4β2 receptors respectively). Has low affinity for α3β4 and α7 receptors (Ki values are 4.8 and 13 μM for huma... |
